A newly single J-Lo made waves with a flowing white sequined jumpsuit from Elie Saab. She completed her look with VRAI x RandM's new illuminate choker.
The Grammy-nominated pop star performed hit single "Otra Noche Sin Ti" while urging the audience to get vaccinated. J Balvin was diagnosed with COVID-19 last summer: "It's not something you ever want to get," he told viewers. "The simple answer is to get the vaccine."
Leave it to Jimmy Kimmel to be the Robin to Ben Affleck's Batman! Affleck looked dapper in a Bruce Wayne-ready suit, while Kimmel playfully donned a retro costume.
Selena Gomez rocked her new blonde locks on the red carpet.
The Duke of Sussex (wearing a J. Crew shirt) addressed audiences onstage. "We are at a defining moment in the global fight against COVID-19. Tonight is a celebration of each of you here, the vaccinated frontline workers in the audience and the millions of frontline heroes around the world," Prince Harry praised the crowd before calling for equal vaccine distribution on a global scale. "This pandemic cannot end unless we act collectively with an unprecedented commitment to our shared humanity."
Chrissy Teigen got a little help from daughter Luna carrying her orange train!
Olivia Munn wowed in golden silk suit.
Jennifer Lopez sang "Sweet Caroline" with her mom Guadalupe Rodriguez, who used to croon the Neil Diamond hit as a lullaby to a young Jennifer. "We've been away too long, but she's here with me tonight and she is vaccinated," Lopez introduced her mother in an adorable moment onstage. "And when I was thinking about what song to sing tonight, I remembered the song she used to always sing to me when I was a baby. So if you would indulge me, I'd love to sing that one tonight."
Newlyweds Leila George and Sean Penn showed their support for the COVID-19 vaccine.
The two pop stars embraced backstage before their respective performances.
The President and First Lady virtually attended the live concert from Washington, D.C.
Eddie Vedder kicked off the performances with a cover of Fugazi's "Give Me The Cure." Vedder lamented on his monumental return to the stage. "This is a feeling we haven't had for quite some time," he told the crowd before launching into Pearl Jam's "I Am A Patriot" song. "There's a microphone, there's a crowd. It feels good."
The South African actress is glowing in a colorful jacket and white pants.
The singer light up the stage—quite literally—in a sparkly jumpsuit by Zuhair Murad. From the explosion of jewels to the feathery details, this look was a sight to see.